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Prasugrel is often used by cardiologists in the setting of clopidogrel failure. It is thought to inhibit close to 80% of platelet activity (whereas clopidogrel is in the range of 40-60%). Given this, the bleeding risk for prasugrel is greater than for clopidogrel and is therefore usually held 10 days prior to surgery.
CABG: Coronary artery bypass graft
BMS: Bare metal stent
DES: Drug-eluting stent
Perioperative Management of Antithrombotic Therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141;e326S-350S.
Updated July 2008
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