Endometrial cancer is a disease in which malignant (cancer) cells form in the tissues of the endometrium. Cancer of the endometrium is different from cancer of the muscle of the uterus, which is called sarcoma of the uterus.

Taking tamoxifen for breast cancer or taking estrogen alone (without progesterone) can affect the risk of developing endometrial cancer. Possible signs of endometrial cancer include unusual vaginal discharge or pain in the pelvis.

The prognosis and treatment options depend on the stage of the cancer (whether it is in the endometrium only, involves the whole uterus, or has spread to other places in the body); how the cancer cells look under a microscope; and whether the cancer cells are affected by progesterone.

Endometrial Cancer Treatment at Moores UCSD Cancer Center