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The first evidence that a group of proteins called phosphatases play a key role in the development of the nervous system, has been shown in fruit flies and mice by researchers at the University of California, San Diego (UCSD) School of Medicine, in collaboration with scientists at the Salk Institute, La Jolla, California. The phosphatases are required for maintenance of neural stem cells and for silencing expression of neuronal genes in non-nervous system tissues.
Gordon Gill, M.D.
The researchers determined that SCPs are a component of a previously identified master gene complex called REST/NRSF, which is known to control neuronal genes. In their investigations with mice and fruit flies, the scientists found that REST/NRSF recruits SCPs only to neuronal genes.
“These findings suggest a way to expand the pool of neuronal stem cells, which could lead to new therapeutic strategies for neurological disorders,” said the study’s senior author, Gordon Gill, M.D., UCSD professor of medicine.
The ability of SCPs to silence genes was first shown by Gill and his post-doctoral fellow Michele Yeo, Ph.D., in an April 28, 2003 study published in the Journal of Biological Chemistry. Yeo is co-first author of the new study in Science, along with Soo-Kyung Lee, Ph.D., a post-doctoral fellow in the lab of Samuel L. Pfaff, Ph.D., associate professor, Salk Institute. Additional authors are Bora Lee, Ph.D. and Esmeralda C. Ruiz, B.S., Salk Institute.
The study was supported by a grant from the National Institutes of Health.
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