Skip Ribbon Commands
Skip to main content
Translate
Donations
<a href="/"><img alt="UC San Diego Health"  oncontextmenu="return false;" style="position:relative;top:10px" src="data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAANwAAAAaCAYAAADc6zIoAAAAGXRFWHRTb2Z0d2FyZQBBZG9iZSBJbWFnZVJlYWR5ccllPAAAAyJpVFh0WE1MOmNvbS5hZG9iZS54bXAAAAAAADw/eHBhY2tldCBiZWdpbj0i77u/IiBpZD0iVzVNME1wQ2VoaUh6cmVTek5UY3prYzlkIj8+IDx4OnhtcG1ldGEgeG1sbnM6eD0iYWRvYmU6bnM6bWV0YS8iIHg6eG1wdGs9IkFkb2JlIFhNUCBDb3JlIDUuMy1jMDExIDY2LjE0NTY2MSwgMjAxMi8wMi8wNi0xNDo1NjoyNyAgICAgICAgIj4gPHJkZjpSREYgeG1sbnM6cmRmPSJodHRwOi8vd3d3LnczLm9yZy8xOTk5LzAyLzIyLXJkZi1zeW50YXgtbnMjIj4gPHJkZjpEZXNjcmlwdGlvbiByZGY6YWJvdXQ9IiIgeG1sbnM6eG1wPSJodHRwOi8vbnMuYWRvYmUuY29tL3hhcC8xLjAvIiB4bWxuczp4bXBNTT0iaHR0cDovL25zLmFkb2JlLmNvbS94YXAvMS4wL21tLyIgeG1sbnM6c3RSZWY9Imh0dHA6Ly9ucy5hZG9iZS5jb20veGFwLzEuMC9zVHlwZS9SZXNvdXJjZVJlZiMiIHhtcDpDcmVhdG9yVG9vbD0iQWRvYmUgUGhvdG9zaG9wIENTNiAoV2luZG93cykiIHhtcE1NOkluc3RhbmNlSUQ9InhtcC5paWQ6QzIzMTg0QzIxNTBCMTFFNTk2NDQ4MUE3Q0MwMjQ3ODkiIHhtcE1NOkRvY3VtZW50SUQ9InhtcC5kaWQ6QzIzMTg0QzMxNTBCMTFFNTk2NDQ4MUE3Q0MwMjQ3ODkiPiA8eG1wTU06RGVyaXZlZEZyb20gc3RSZWY6aW5zdGFuY2VJRD0ieG1wLmlpZDpDMjMxODRDMDE1MEIxMUU1OTY0NDgxQTdDQzAyNDc4OSIgc3RSZWY6ZG9jdW1lbnRJRD0ieG1wLmRpZDpDMjMxODRDMTE1MEIxMUU1OTY0NDgxQTdDQzAyNDc4OSIvPiA8L3JkZjpEZXNjcmlwdGlvbj4gPC9yZGY6UkRGPiA8L3g6eG1wbWV0YT4gPD94cGFja2V0IGVuZD0iciI/Pjl+1BoAAA2qSURBVHja7FwJmBXFEe7lWmC5wYCLQQ455RIbMAG5Eo6IElHEKJqAH1FEliiRaBAURaNfNCSICiIqLpAEEYmgQhJUSIgmZhJOiQQRVskGOV0wAsuxqer+573a2Zn3ZuXNcr36vpo3O9Mz011TVf1XVc9mKKWXKaWqKH86SnyXUs7G+CHdhDbPElfyaX+Y+PvUfhfaVqPNcOIriTsQN0C7E8R7iLcTryV+n/gNum6nCiRdjzYjifsTtyOuixNfEhcQ5xH/i3g03eewOiWkv0abucSZAQ0KRX+3YexvU38PqLOK9HS8Iz/idz+LxvxboU8zE8jsCPHNcZ06sykDg76QNkuFkL4g/g4NcnUCoXaizXLi84i3El9B7f8tzg+kzYs4v5d4BvFfiA8Sn0/ch3gEcWVcMI6u/2XAswbTJpe4Gp7J+5/g7y4wxEZoTGNxPjnFCtcG/fw6DhxAn/9HXMf2UXUjziI+RvwK8QTq97azyOhq0WY28bXiIDvfeTTO4z7tO0BmrlP+lHgAtd1UBn1lY29OvI+el1/Ka6vhWtI5Z29pLryNuAicG/KaaWh/r+c4GZs+jnNr4Pn9rm9MvAntJge0uYS4EG0mBbSpSrwUbS4+TRTuQSHPX/icJ1ShxxAfQJuDcFLeduSQNCEKvRxO7kwyug5CBltCtH9CtH+gDPr3AvE2oavDQ15Xm3gJ8Q7R315hriwn9j8T+/tC9ng/fnd6LP5F3Puo9XBBcMBhSDkQnr9WwDMI0qqKmEUfDrgPw7Rh6Hf100Tb9gfI1u3zIeKnMNMVYLZeCE8vaSjxrYDST5xh09x/xf5/QrSXbfKj755zC23GeOwgzHX8bhl1TS3tE8tFMIoRgJFML1PnPk7SeYZRTycwuM74JbjqFCW4D8O2RwCHTzcqTNDvDbT5Mf6ognhG0oeIe5g2nmEGV1jK9kWe/EEZkPMGwpOg2ewC4t/5XMew+KnTweCuE/uLQ15DU7v6R8C5CvjtZKFjQuFNLZ7gOWPoJeLd2L+MxtlFjIkTSgyT+xLfGTHEupQ4h7iZOrcogSNXLRLoW+EpNjjN99OyRyG9zGbi6QEn3URCfRuE68yz7307nDh5XRwY5DlPs5yzgvhEhMZ2tbLZ4ieJf6PS5NIdqbxZhRR37kIVLzEUIdN0svQ8vDvTDcTtSTnuJuVbXgpl4hJGUxgtxU5cPnAOJmjP8LYJtVkjjrVSNoNGcYazJYIXu1bsd/X0h99TYwuX/UonuqGyWdqK1kE5CeTOyRrVEhD+mJWFiaE5Q0yOT7XGMXlNDdrw+DNtvB7J+MO+S87yXkRcFXHeluBQQ3OWmDnD6mLY7LWuiJltHPE1xK+Vso8N0EfWtQ1yJky1wdUU+wdS45GdBTSA7ghuFeDVMjr2N/qdnNjwdF0kWm5CQP4xFIqUU7MXHx2vgemetOHMWFvEoAVWKU3WM9dC2th9VypbNkllvU8qcWM8ZxZtehA3w7vi+HiO6McVtHkML/fPytYmGRY61jMbOOq2rY0g/3twhFzCaQeF3GDv6zxojSsmE3agjyNB8CGSYwR39V7IPrcMDa0j+n858bs42M3GX3o89WUR2rFxjSImp6x4zH8nrgGovtHK0EmGvDgUYp1zS1acdf9cnB+G2M/bRy7zzIC+oeTGMtP9qf36KAyuVkSQK8eWF0yWrraYBVzDu5farPS58I/Elyhb/7vcekJdXtmaI2c12WBG4hmrUO+bp2yhXtmyhXoHiYwhxFxf45pZL+IbEXumig6JfTfpdBvgpU/QrocC+rGhNqf+I8NnUtucJV5pY0GOac2Yl0FmU60yGllUgDO5wcpCTxHG1gxy45IOF57n4zj37U0bd2qaBZyJIcdHM6Sek6RNmwBj48ztaszIZDgO4n19mR0nvxM9BEZ3D/GjuLBRfLbXI/C+CLrrpshsB+mb+/4nwwnzooyrk/S9PMKCQovCjG3NhQPne1wbRdJEwrSMFBvdC4CFjwECSfhFRqHnAvq4L6kmjI3pvTjsMNmlp3F8KDyi+4yC4jOI+pVVUOd+m001Xu1tnGuXYtn5KAD32XmtJDQ3kGc63t/IuLGZa7j/6wDt78PBngKmPiRkcQywqcjOXKqfeMgcQPD5cWMz13ByZzj+uA/oI2piuMuzx8S4sZm+/JU2WLESKxn1xO+nHmida1GXGVOfCPo4Ejo/0Do5h0OEWTjXNipIKafdGrZom0rY5fD9f4pC8t2AmVk4ydN4RwsNnX3WeIxXY6PzFp5dBa0OGCz7fVycawQML2l3fHwppWpi35v98kLznph5WIF2YCaWxLFKB0Au+cL3w6lImTLk+QzxKSe83AJ7d2F43vfwAWArt/8RZp9kxImf4UlgI2dhO3uO8YzaG3+s8RnrTjGD1rZoxyTaXvH0mYvbeXCUjSIwuME23DFOzKVdQpciMbgdmPbd+/KMFMHSHGePFazmmepZG0/FFOtJGJ/r7f1gTJi1i+XsDBcYh5ZP8aDq+ShRELXHbxV/uGlonUAcbl+zAtoWwODcsksvcS6oXOMaXO+IZzeJJGYKh+gdK+ThrLOxuS+577JSBP2kMMXZ6jl2BL9VIzI4hx6gNwgo1zUag4s9jyCDvop2nkNCAZlMfUdJT24WyXICJBtJhjC0rAzTb22KzwahYmXyoE7HEPf+IK5ounnxLKOJ77I97dxZ5ChQhR/twW9dWx9NFBOdFNUW+73hbMMmWmpa1GOy5/VVfJ1mFBRKV8oFxF9hPYDrOSVsfEfsXxm9npqYbIyYtXhMLSFwXofIEHQ7kgvjke4tChdTObvL0OC6if2VSdq6kDMbS+mS0QphTFNQL1UiMVMd8nkVxzIDoG1QkqdShHKRfWgR0tA4q7hK2aV+s5HZrBwwO6aKtpfW4OR6x6YhH9LQ4+2UzV7F6Lt2acxXJa6fhVn1YLzrZnHgGDJwXDL4mY1dGOM7HN9x7DcjxMOPlp2tGRn1EQq2MMkFO0Viql8I+ZywCSLjaK63EMws3GVD5OVJnM3tb9d3FtOFLNQw/ahuXNaBs2AqSK7HHBBCljnIFna2Y3V4Rv8h8RQRf0dBJ0prcFvETPWNBIKW9M2SEMjUGxaLGXDaSQyCP+NZBeNJJGQ+30QoLGPpQSJjdSv16yMfZTld6GHxLqaHmFnfFfujQz6D23Gmlz8lmUD8FrJ/nDrv5/k0SMZtzQPu1yJJjJcqWq/iGdyRifWSEY1xsEzP0Jg8iZPAGLbMSBicySYuERm4UUmUvD+gG1fSd3hOjhFe8hpq+7gHxoSlAsyiP0nSLkckHV5G/NYqQRLiW2Us5wDYxyUJ8xnKD3CAa4oh6lrmG7H34mPRw5K8q4pWWc2sTc7IWWpT/VzmKPHumH4vZoOrfO6XJZIlcxM8OKuUsDOz5LVmlcZLwgE/kuD6BkLWnnduspsXlfK9uSincgQGZ2iSiIXYSG4MeIE8tc/DHxN8FCLfQpSY0TGMW21XRpiX770fQVjtB43cuJKErGdgqY4nKOZibeyzFV5JcBf25YwmxsHFWjVWnPP2p3rcSLSfoN1yQJ1SJEG6FHc4vPTHGAnXkSbj4GLAusMljTKmRPK7wlHC8z+XxOiOoe0o+070Wg+vwfd2E61MDbR0v2AgeerzPfd7AAaxFjFSEHUoPiMmRU1txf7FHr3Mi+uSvj8A9ewSseVQJIQU1t/OFPLK8MjXdQz1AxJDrf0nDF3PR28knRc3WKv3PsVpU9Xn9YuX4sBWKMZ+QDEukDaDBxwb/1Te1zAbWMM1KxnKi2CblxUx7ue09gXIkvHMdL3PPb5Uxf8FBPcnH0rYFgZTiLhsUnyNpHkhnMDpDny9EB6rKzKaK+C5chDD7EVGa5owltkWmpi0cyPEWc/AEx8FTFuB7/oUvmYYANmN9xjz53BmdYQB7cOzyWCct3zGzko3HA5LQen4me/bbB2v7jcFXbe/bABv4t1Ut3Jynse92OnMD+GEOTzoZI1O3w5nxorM5Rau1w2EA1tlldrvW0fdG+jnHpHxVOgbO+o1dkF2LJP4bcRc48UkwPJ9FLJfDrnNEegkD04qD++D2HkItTz3Pwfwsi4uX/SFfnRFLMsZxTuBigahn0xcv7xdyLehRXAmU8rPWoTEC8No7vc46LYLrfk9/RO63hkyQwLPlK9mJlgNEit+tkAauhKMbidiiFXhi9qaDYrX/bWHF6kEuMgeZJsdIHfYr+ZllK4VYomGGGgNKHA+BvgH//8LYjzqzYg1C9F2gW2reyCBkInAfBEMzo9+DWNr4J/AcNdzmozhkOTZTyPHbZadBJkzYyR+s8JarGRwPXQvZOIaYjyHkURaYmtDuiUSCesBz73PrIV7MFxjp8EfDb8qnOZgvDtXVgQ5nT8l6PegJAhA9r+OKvF1RAmiWMzBd45mTWVfxOxVYZh51ohiS7564D1UhREtsF+kmJl6LKDpPujyriT9Y5leZ2c5M/5CTEitA/q6Gu+si0rTuUq8KkR/kfx7Qv1z/LuAW9Iyizxpkqaz1NgyAHEPhihOuzHrurTc0pSmr250mzFzJajZ6fb4R0avp+UVHZVPi+BcoOxNiGkoFskmaJn9EYW/h+zsl03xcfZYJIj4S4ib6NyRtMyioYy0CM6ZWY7XE+Yg4cBJqEMIKThxwB+v5tpvAtMUJf1fgAEALx+4S33OVUkAAAAASUVORK5CYII=" /></a>
menu iconMenu
search iconSearch

Decision-Makers Seek Internal Balance, Not Balanced Alternatives

 

October 25, 2007  |  

A brain in balance, rather than the promise of pain or pleasure, may form basis of decision-making for psychiatric patients

A researcher at the University of California, San Diego (UCSD) School of Medicine suggests that psychiatrists may need to approach the treatment of psychiatric patients from a new direction – by understanding that such individuals’ behavior and decision-making are based on an attempt to reach an inner equilibrium.

In a special section in the October 26 issue of the journal Science, Martin Paulus, M.D., professor in UCSD’s Department of Psychiatry, has compiled a body of growing evidence that human decision-making is inextricably linked to an individuals’ need to maintain a homeostatic balance.

“This is a state of dynamic equilibrium, much like controlling body temperature,” said Paulus.  “How humans select a particular course of action may be in response to raising or lowering that ‘set point’ back to their individual comfort zone.  In people with psychiatric disorders or addictions, the thermostat may be broken.”

Up to now, according to Paulus, psychiatrists and others have looked at the decision-making process as a considered series of options and values. 

“What has never been considered closely, but should be, is the state of the decision-maker,” Paulus said.  According to the researcher, this homeostatic state – the tendency to maintain internal stability, due to the mind and body’s coordinated responses to any stimulus that disturbs the normal condition – is altered in individuals with addictions and psychiatric disorders such as schizophrenia or anxiety.  “This disturbance of homeostatic balance leads to dysfunctions in decision-making – which helps explain why such patients make seemingly bad choices,” he said.

Recent neuroimaging research shows strong support for the homeostatic nature of decision making, according to Paulus.  “For example, interoceptive information – which is related to the body’s internal state or sense of balance – is integrated in a particular part of the brain called the anterior insular cortex,” he said.  The same brain structures implicated in the urge to take drugs are involved in other biological urges, Paulus added, suggesting that a homeostatic approach could have a broad impact on treatments that seek to control addictions or psychiatric disorders, and will lay the groundwork for new areas of research. 

The question addressed in part by this paper are whether changes in decision-making behavior and associated brain functions are a result of pre-existing characteristics – which may predispose individuals to use drugs – or as a consequence of long-term use.

“Decision-making dysfunctions and resultant altered neural processing could provide a biomarker to identify those at high-risk for addictive behaviors,” said Paulus, who added that much additional research is needed before scientists could begin to use such an approach. 

In an upcoming paper in the journal “Dialogues in Clinical Neuroscience,” Paulus cites the complex affective, cognitive and behavioral phenomena that come into play during decision-making.  “The interoceptive system is able to connect with various physiological systems in the brain to orchestrate a complex set of responses,” he said, adding that craving and urges are among the most notable responses that play important functions in maintaining homeostasis.  Insights into how pleasure and urge are integrated in the brain and how this process is modulated can play an important role in the understanding of – and possible future treatment of – drug addiction, according to Paulus.

Funding for the Science paper was provided by a grant from the National Institute on Drug Abuse and a U.S. Department of Veterans Affairs merit grant.

# # #

Media Contact: Debra Kain, 619-543-6163, ddkain@ucsd.edu




Media Contact

Related News

9/1/2015
An international research team, headed by Joseph Vinetz, MD, professor of medicine at University of California, San Diego School of Medicine and director of the UC San Diego Center for Tropical Medici ...
8/28/2015
Four University of California, San Diego School of Medicine researchers have been selected to receive the newly established National Cancer Institute (NCI) Outstanding Investigator Award. The multi-mi ...
8/27/2015
Degenerating neurons in patients with Alzheimer’s disease (AD) measurably responded to an experimental gene therapy in which nerve growth factor (NGF) was injected into their brains, report researcher ...
8/24/2015
Patty Maysent, MPH, MBA, has been appointed interim Chief Executive Officer of UC San Diego Health, bringing to the role more than 25 years of exceptional executive experience in hospital leadership a ...


Share This Article



Follow Us