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Awards boost CIRM funding to UC San Diego to more than $78 million
Two scientists at the University of California, San Diego School of Medicine – Catriona Jamieson, MD, PhD, and Alysson Muotri, PhD – have received grants from the California Institute for Regenerative Medicine (CIRM) for stem cell research. The grants are part of $67 million in Early Translation II Awards announced by CIRM today, which are designed to move research out of the lab and into the clinic.
Jamieson, assistant professor of medicine and director of stem cell research at UCSD’s Moores Cancer Center, received a grant for $3,341,758 to develop a panBCL2 antagonist as a dormant leukemia stem cell survival inhibitor.
While also common in adults, leukemia is the most frequent form of cancer in children and teenagers. Chemotherapy has vastly improved the outcome for patients with leukemia, but many still die due to recurrence and development of drug-resistance in leukemia cells.
Catriona Jamieson, MD, PhD
The proposed approach looks to eliminate leukemia stem cells by targeting BCL2 family members and tyrosine kinases that fuel survival, establishing therapeutic efficacy in novel cancer stem cell assays. In collaboration with Coronado Biosciences, the researchers will then develop methods for large-scale production, analysis and toxicity studies to advance the panBCL2 inhibitor to pre-clinical and clinical development.
The CIRM board also awarded a $1,481,471 million grant to Alysson Muotri, PhD, assistant professor of pediatrics, to help design a future drug-screening system for autism spectrum disorders (ASD) that employs human neurons.
Alysson Muotri, PhD
“These are experiments that have never been possible before,” said Muotri. “We hope they will help us better understand the causal molecular mechanisms of ASD, find possible biomarkers for the disease and identify specific therapeutic targets.”
Autism affects one in 110 children in the United States, according to the Centers for Disease Control and Prevention. An estimated 1.5 million Americans live with the effects of the disease, which occurs in all ethnic and socioeconomic groups and affects every age group, though males are four times more likely to have ASD than females.
The grants to Jamieson and Muotri boost total CIRM funding for UCSD projects to more than $78 million since the first awards were given in 2006.
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Pediatrics & Adolescent Medicine
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