Skip Ribbon Commands
Skip to main content
Translate
Translate
menu iconMenu
search iconSearch

Two Studies Identify Potential New Drug for Crohn’s Disease and Ulcerative Colitis

 

August 21, 2013  |   

Vedolizumab, a new intravenous antibody medication, has shown positive results for treating both Crohn’s disease and ulcerative colitis, according to researchers at the University of California San Diego, School of Medicine. The findings, published in two papers, will appear in the August 22 issue of the New England Journal of Medicine (NEJM).

 

William Sandborn 

Director of the Inflammatory Bowel Disease Center at UC San Diego Health System

William Sandborn, MD, principal investigator of the Crohn’s disease study, said the results offer new hope to the more than one million Americans who suffer from inflammatory bowel disease (IBD) and do not respond to treatment. Both studies showed that the use of vedolizumab resulted in remission and discontinued use of prednisone, a common yet difficult to tolerate drug used to treat both diseases.

 

“The two trials showed highly encouraging results for patients suffering from moderate-to-severe Crohn’s disease and ulcerative colitis when conventional therapy such as steroids, immune suppressive drugs and anti-tumor necrosis factor (TNF) biologic drugs failed,” said Sandborn, of the Division of Gastroenterology at UC San Diego School of Medicine and director of the Inflammatory Bowel Disease Center at UC San Diego Health System. “This is a disease modifying drug.  In many cases of patients with ulcerative colitis, complete healing of the bowel was observed and maintained with continued use of vedolizumab.”

 

 
Vedolizumab is targeted to disease within the digestive tract so other areas of the body remain unaffected. It blocks immune system cells that release proteins called cytokines that trigger inflammation, causing tissue damage and diarrhea to move into the small intestine and colon. The targeted nature of the medication helps reduce troublesome side effects such as weight gain, nausea and headaches caused by other treatment options. Current treatments such as steroids and immunosuppressive medications broadly suppress the immune system, which can also put the patient at risk for infections.

 

“Inflammatory bowel disease causes severe ongoing bouts of illness that adversely affect a patient’s quality of life at home and work,” said Sandborn. “These latest findings will potentially lead to a new drug therapy that will improve a patient’s overall lifestyle.”

Crohn’s disease and ulcerative colitis are forms of inflammatory autoimmune diseases, impacting the small intestine and colon. Clinical symptoms include abdominal pain, diarrhea, intestinal bleeding, fecal urgency and weight loss. Serious complications such as bowel obstruction, colon cancer, malnutrition and abscesses can also occur, resulting in hospitalization and the possible surgical removal of portions of the bowel and colon. 

Eight hundred and ninety five patients were part of the ulcerative colitis trial conducted in 34 countries, and 1,115 patients were part of the Crohn’s disease clinical trial conducted in 39 countries. Eligible patients for both trials were between 18 and 80-years-old and were treated for 52 weeks in the placebo-controlled studies. Benefits could be seen six weeks into the study.  

Researchers who also participated in the Crohn’s disease and ulcerative colitis trials include: Brian G. Feagan, MD, Robarts Clinical Trials, Robarts Research Institute, and the Departments of Medicine and of Epidemiology and Biostatistics, University of Western Ontario, London;  Paul Rutgeerts, MD, PhD, Katholieke Universiteit and University Hospital Gasthuisberg, Leuven, Belgium;  Stephen Hanauer, MD, University of Chicago, Chicago; Jean-Frédéric Colombel, MD, Departement d’Hepato-gastroenterologie et Centre d’Investigations Cliniques, Centre Hospitalier Regional Universitaire de Lille, Universite Lille Nord de France, Lille, France;  Bruce E. Sands, MD, Icahn School of Medicine at Mount Sinai, New York;  Milan Lukas, MD, PhD, General Faculty Hospital, Prague, Czech Republic; Richard N. Fedorak, MD, University of Alberta, Edmonton, AB;  Scott Lee, MD, University of Washington, Seattle; Brian Bressler, MD, University of British Columbia, Vancouver;  Gert Van Assche, MD, PhD, Katholieke Universiteit and University Hospital Gasthuisberg, Leuven, Belgium;  Jeffrey Axler, MD, Toronto Digestive Disease Associates, University of Toronto, and Mount Sinai Hospital, Toronto;  Hyo-Jong Kim, MD, PhD, Kyung Hee University Hospital, Seoul, South Korea;  Silvio Danese, MD, PhD, Istituto Clinico Humanitas, Milan;  Irving Fox, MD, Maria Rosario, PhD, Serap Sankoh, PhD, Jing Xu, PhD, Kristin Stephens, BA, Catherine Milch, MD, Asit Parikh, MD, PhD, and Tim Wyant, PhD, Millennium Pharmaceuticals, Cambridge, MA.

The study was supported by Takeda Pharmaceuticals, Inc.

The Department of Gastroenterology at UC San Diego Health System is nationally recognized for its innovative and comprehensive care of patients by a multidisciplinary team of specialists in gastroenterology, endoscopy, oncology, surgery, transplantation and radiology.  The Inflammatory Bowel Disease Center is dedicated to diagnosing and treating people with IBD from around the world. The center’s leadership in IBD medical research means patient access to clinical trials for the newest therapies and advanced surgical techniques for the treatment of this challenging condition.

# # #

Media Contact: Michelle Brubaker, 619-543-6163, mmbrubaker@ucsd.edu



Media Contact

Related News

2/25/2015
Writing in the February 25 online issue of Nature, an international team of scientists, headed by researchers at the University of California, San Diego School of Medicine, report finding new links be ...
2/23/2015
Researchers at University of California, San Diego School of Medicine have discovered that the inflammatory molecule LTB4 promotes insulin resistance, a first step in developing type 2 diabetes. What’ ...
2/18/2015
Researchers at University of California, San Diego School of Medicine used algae as a mini-factory to produce a malaria parasite protein. The algae-produced protein, paired with an immune-boosting coc ...
2/13/2015
While genomics is the study of all of the genes in a cell or organism, epigenomics is the study of all the genomic add-ons and changes that influence gene expression but aren’t encoded in the DNA sequ ...
1/26/2015
To better understand PLA2 enzymes and help drive therapeutic drug development, researchers at University of California, San Diego School of Medicine developed 3D computer models that show exactly how ...
1/22/2015
Researchers at University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences and the Bridge Institute at the University of Southern California report the first crystal stru ...
1/20/2015
Upending decades-old dogma, a team of scientists at the University of California, San Diego School of Medicine say enzymes long categorized as promoting cancer are, in fact, tumor suppressors and that ...
1/15/2015
Researchers at UC San Diego School of Medicine previously reported that a drug used for almost a century to treat trypanosomiasis, or sleeping sickness, reversed environmental autism-like symptoms in ...