2014 Archived News Releases

Mutant Protein in Muscle Linked to Neuromuscular Disorder
April 16, 2014
Sometimes known as Kennedy’s disease, spinal and bulbar muscular atrophy (SBMA) is a rare inherited neuromuscular disorder characterized by slowly progressive muscle weakness and atrophy. Researchers have long considered it to be essentially an affl... (More)

Breaking Bad Mitochondria
April 15, 2014
Researchers at the University of California, San Diego School of Medicine have identified a mechanism that explains why people with the hepatitis C virus get liver disease and why the virus is able to persist in the body for so long. The hard-to-k... (More)

Splice Variants Reveal Connections Among Autism Genes
April 10, 2014
A team of researchers from the University of California, San Diego School of Medicine and the Center for Cancer Systems Biology (CCSB) at the Dana-Farber Cancer Institute has uncovered a new aspect of autism, revealing that proteins involved in auti... (More)

For Good and Ill, Immune Response to Cancer Cuts Both Ways
April 07, 2014
The difference between an immune response that kills cancer cells and one that conversely stimulates tumor growth can be as narrow as a “double-edged sword,” report researchers at the University of California, San Diego School of Medicine in the Apr... (More)

Cancer and the Goldilocks Effect
April 03, 2014
Researchers at the University of California, San Diego School of Medicine have found that too little or too much of an enzyme called SRPK1 promotes cancer by disrupting a regulatory event critical for many fundamental cellular processes, including p... (More)

UC San Diego Medical Center Named Among 100 Great Hospitals in U.S.
April 02, 2014
The University of California, San Diego Medical Center in Hillcrest has been named one of  “100 Great Hospitals in America” by Becker’s Hospital Review, a publishing group that conducts hospital and healthcare news and analyses, which described the ... (More)

Good Vibrations: Using Light-Heated Water to Deliver Drugs
April 01, 2014
Researchers from the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using light to activate dr... (More)

Gulf War Illness Not in Veterans’ Heads, But in Their Mitochondria
March 27, 2014
Researchers at the UC San Diego School of Medicine have demonstrated for the first time that veterans of the 1990-91 Persian Gulf War who suffer from “Gulf War illness” have impaired function of mitochondria – the energy powerhouses of cells. The ... (More)

Patches of Cortical Layers Disrupted During Early Brain Development in Autism
March 26, 2014
Researchers at the University of California, San Diego School of Medicine and the Allen Institute for Brain Science have published a study that gives clear and direct new evidence that autism begins during pregnancy. The study will be published in... (More)

Ferrara Receives Gairdner Prize, Canada’s Highest Honor in Life Sciences
March 26, 2014
Napoleone Ferrara, MD, distinguished professor of pathology at the University of California, San Diego School of Medicine and senior deputy director for basic sciences at UC San Diego Moores Cancer Center, was named today among eight recipients of t... (More)

Brain Differences in College-aged Occasional Drug Users
March 25, 2014
Researchers at the University of California, San Diego School of Medicine have discovered impaired neuronal activity in the parts of the brain associated with anticipatory functioning among occasional 18- to 24-year-old users of stimulant drugs, suc... (More)

Stem Cell-Derived Beta Cells Under Skin Replace Insulin
March 25, 2014
Scientists at University of California, San Diego School of Medicine and Sanford-Burnham Medical Research Institute have shown that by encapsulating immature pancreatic cells derived from human embryonic stem cells (hESC), and implanting them under ... (More)

Bariatric Surgery Decreases Risk of Uterine Cancer
March 24, 2014
Researchers at the University of California, San Diego School of Medicine and Moores Cancer Center report that bariatric surgery resulting in dramatic weight loss in formerly severely obese women reduces the risk of endometrial (uterine) cancer by 7... (More)

New Therapeutic Target Discovered for Alzheimer’s Disease
March 17, 2014
A team of scientists from the University of California, San Diego School of Medicine, the Medical University of South Carolina and San Diego-based American Life Science Pharmaceuticals, Inc., report that cathepsin B gene knockout or its reduction by... (More)

Mother Delivers Baby, Develops Heart Disease
March 11, 2014
Three weeks after delivering her first child, Amanda began to suffer from extreme fatigue, headaches, a tight chest and stomach pain. An initial diagnosis of pneumonia changed for the worse: Amanda was experiencing heart failure. The 28-year-old’s l... (More)

Anti-psychotic Medications Offer New Hope in the Battle Against Glioblastoma
March 07, 2014
Researchers at the University of California, San Diego School of Medicine have discovered that FDA-approved anti-psychotic drugs possess tumor-killing activity against the most aggressive form of primary brain cancer, glioblastoma. The finding was p... (More)

Kawasaki Disease and Pregnant Women
March 06, 2014
In the first study of its type, researchers at the University of California, San Diego School of Medicine have looked at the health threat to pregnant women with a history of Kawasaki disease (KD), concluding that the risks are low with informed man... (More)

Vitamin D Increases Breast Cancer Patient Survival
March 06, 2014
Breast cancer patients with high levels of vitamin D in their blood are twice as likely to survive the disease as women with low levels of this nutrient, report University of California, San Diego School of Medicine researchers in the March issue of... (More)

UC San Diego-Human Longevity Inc. Agreement Seeks to Accelerate Medical Science
March 04, 2014
The new collaborative research agreement between Human Longevity Inc. (HLI) and the University of California, San Diego, announced today, represents a significant and necessary step in efforts to research and translate the potential of the human gen... (More)

In First Moments of Infection, a Division and a Decision
March 04, 2014
Using technologies and computational modeling that trace the destiny of single cells, researchers at the University of California, San Diego School of Medicine describe for the first time the earliest stages of fate determination among white blood c... (More)

California’s First MRI-Guided Laser Treatment for Brain Cancer
February 24, 2014
Using a novel magnetic resonance imaging (MRI)-guided laser technology, neurosurgeons at UC San Diego Health System have successfully treated a malignant tumor deep inside a patient’s brain. This is the first time that this FDA-approved laser-based ... (More)

Study Evaluates Role of Infliximab in Treating Kawasaki Disease
February 24, 2014
Kawasaki Disease (KD) is a severe childhood disease that many parents, even some doctors, mistake for an inconsequential viral infection. If not diagnosed or treated in time, it can lead to irreversible heart damage. Signs of KD include prolonged ... (More)

Improving Knee Replacements
February 18, 2014
Each year, approximately 600,000 total knee replacement procedures are performed in the United States, a number that is expected to rise exponentially in the next decade as the population ages. Successful surgeries require precise alignment in the k... (More)

Child obesity: Cues and Don’ts
February 14, 2014
Among the multiple factors that can cause obesity is an abnormal neurocognitive or behavioral response to food cues. The brain becomes wired to seek – and expect – greater rewards from food, which leads to unhealthful overeating. Attention modifica... (More)

Protein Switch Dictates Cellular Fate: Stem Cell or Neuron
February 13, 2014
Researchers at the University of California, San Diego School of Medicine have discovered that a well-known protein has a new function: It acts in a biological circuit to determine whether an immature neural cell remains in a stem-like state or proc... (More)

I Smoke, But I’m Not a Smoker
February 11, 2014
While smoking among California adults has dramatically declined in recent decades, researchers at the University of California, San Diego School of Medicine report there is a surprisingly large number of people who say they use cigarettes, but don’t... (More)

Global Regulator of mRNA Editing Found
February 06, 2014
An international team of researchers, led by scientists from the University of California, San Diego School of Medicine and Indiana University, have identified a protein that broadly regulates how genetic information transcribed from DNA to messenge... (More)

Split Decision: Stem Cell Signal Linked With Cancer Growth
February 03, 2014
Researchers at the University of California, San Diego School of Medicine have identified a protein critical to hematopoietic stem cell function and blood formation. The finding has potential as a new target for treating leukemia because cancer stem... (More)

CIRM Awards $8.165 Million in Basic Biology Awards to UC San Diego
January 30, 2014
Eight stem cell scientists at the University of California, San Diego have been awarded a total of $8.165 million to fund research tackling significant, unresolved issues in human stem cell biology. The California Institute for Regenerative Medici... (More)

Scientists Discover New Genetic Forms of Neurodegeneration
January 30, 2014
In a study published in the January 31, 2014 issue of Science, an international team led by scientists at the University of California, San Diego School of Medicine report doubling the number of known causes for the neurodegenerative disorder known ... (More)

How DNA Damage Affects Golgi – The Cell’s Shipping Department
January 30, 2014
In studying the impact of DNA damage on the Golgi, a research team from the University of California, San Diego School of Medicine and the Ludwig Institute for Cancer Research have discovered a novel pathway activated by DNA damage, with important c... (More)

UC San Diego Health System Top Ranked by Healthgrades
January 29, 2014
UC San Diego Health System is a recipient of Healthgrades’ “Distinguished Hospital Award for Clinical Excellence.” Top performing hospitals were selected based on clinical excellence across a broad spectrum of care in specialty areas such as cardiac... (More)

H.M.'s Brain Yields New Evidence
January 28, 2014
3D model of famous amnesiac's brain helps illuminate human memory During his lifetime, Henry G. Molaison (H.M.) was the best-known and possibly the most-studied patient of modern neuroscience.  Now, thanks to the postmortem study of his brain, bas... (More)

Putting a Brake on Tumor Spread
January 23, 2014
A team of scientists, led by principal investigator David D. Schlaepfer, PhD, a professor in the Department of Reproductive Medicine at the University of California, San Diego School of Medicine, has found that a protein involved in promoting tumor ... (More)

Drug Discovery Potential of Natural Microbial Genomes
January 22, 2014
Advanced genetic technique yields novel antibiotic from ocean bacteria Scientists at the University of California, San Diego have developed a new genetic platform that allows efficient production of naturally occurring molecules, and have used it t... (More)

Nationwide Minimally Invasive Surgery Rates Triple for Pancreatic Disease
January 15, 2014
Researchers at University of California, San Diego School of Medicine report a three-fold increase in the use of minimally invasive surgery (MIS) across the nation for patients with pancreatic disease.  Although adaptation of MIS for this difficult-... (More)

UC San Diego Health System Among Nation’s Best in Women’s Health
January 15, 2014
Named to Becker’s Hospital Review’s “100 Hospitals with Great Women’s Health Programs”  UC San Diego Health System has been featured in the latest Becker’s Hospital Review list of “100 Hospitals with Great Women’s Health Programs.” Hospitals were ... (More)

Keeping Stem Cells Pluripotent
January 13, 2014
By blocking key signal, researchers maintain embryonic stem cells in vital, undifferentiated state While the ability of human embryonic stem cells (hESCs) to become any type of mature cell, from neuron to heart to skin and bone, is indisputably cru... (More)

Study Demonstrates Need to Change Scoring System for Heart Disease
January 13, 2014
Dense Heart Plaques May Have Protective Quality A study led by researchers at the University of California, San Diego School of Medicine shows that one of the most widely used systems for predicting risk of adverse heart events should be re-evaluat... (More)

Football Fans Team Up for Organ Match
January 08, 2014
Random stadium seat assignment leads to lifesaving transplant surgery In October 2013, Louis Munoz donated one of his kidneys to William Lynch. The organ match would not have occurred without a bit of serendipity and a big love of football. Munoz a... (More)

Treating the inner animal in all of us
January 08, 2014
New veterinary and comparative medicine center advances health care, human and otherwise Discoveries about how diseases arise or are transmitted in animals can be useful in understanding the same sorts of afflictions in humans. Similarly, new ther... (More)

Conference Attracts International Experts in Field of Mindfulness and Child Development to San Diego
January 07, 2014
Featured Speakers include Daniel Siegel, Sharon Salzberg and Congressman Tim Ryan Experts in the field of mindfulness will gather in San Diego from Feb. 7-9 to share the latest advancements in education, clinical care and research as it applies to ... (More)

The Mouse That ROR’ed
January 02, 2014
ROR1 oncogene combines with another to accelerate, worsen blood cancer Researchers at the University of California, San Diego School of Medicine report that an oncogene dubbed ROR1, found on chronic lymphocytic leukemia (CLL) B cells but not normal... (More)