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Dosing

Enoxaparin (Lovenox)—comes in prefilled syringes 30mg, 40mg, 60mg, 80mg, 100mg, 120mg, 150mg

  • Therapeutic enoxaparin = 1.5-2mg/kg/day or 1mg/kg/bid
  • Prophylactic enoxaparin = 30-40mg/day
  • Dose adjustment required/precaution advised for CrCl < 30mL/min

Dalteparin (Fragmin)—comes in prefilled syringes 2500units, 5000units, 7500units, 10,000units, 12,500units, 15,000units, 18,000units, 25,000units

  • Therapeutic dalteparin = 200units/kg/day
  • Prophylactic dalteparin = 2500-5000units/day
  • Dose adjustment required/precaution advised for CrCl < 30mL/min
  • 5000 units/day may be reasonable for patients undergoing dialysis based on a study from 2010

 

 

 

Reference: 

Schmid P, Brodmann D, Fischer AG, Wuillemin WA. Prospective observational cohort study of bioaccumulation of dalteparin at a prophylactic dose in patients with peritoneal dialysis. J Thromb Haemost. 2010 Apr;8(4):850-2. Epub 2010 Jan 17.