An overview of the CIRM Alpha Stem Cell Clinic
at UC San Diego Health
The mission of the Alpha Stem Cell Clinic at UC San Diego Health is to accelerate the development, implementation and administration of safe and effective stem cell-based human therapies.
About the Alpha Stem Cell Clinic
The Alpha Stem Cell Clinic at UC San Diego Health is one of five “alpha clinics” in a network designated by the
California Institute for Regenerative Medicine (CIRM), the state’s stem cell agency. It is the cell therapy arm of the
Sanford Stem Cell Clinical Center that specializes in early phase, first-in-human trials.
The alpha clinics are intended to create the long-term, networked infrastructure needed to launch and conduct numerous, extensive clinical trials of stem cell-related drugs and therapies in humans, including those developed by independent California-based investigators and companies. These trials are requisite before any new drug or treatment can be approved for clinical use.
The clinics will emphasize public education to raise awareness and understanding of stem cell science. This will combat “stem cell tourism” and the marketing of unproven, unregulated and potentially dangerous therapies. The clinics will also help establish sustainable business models for future, approved stem cell treatments.
Alpha Stem Cell Clinics Network
To learn more about participating Alpha Clinics, please visit each clinic's dedicated webpage:
Our current clinical trials include:
Chronic Heart Failure
Chronic Lymphocytic Leukemia
Spinal Cord Injury
Type 1 Diabetes
A Prospective, Multicenter, Open-Label, First-in-Human Phase 1/2 Study With Two Cohorts to Evaluate the Safety, Tolerability, and Efficacy of Various Doses of VC-01™ Combination Product in Subjects With Type 1 Diabetes Mellitus
One-Year, Multicenter, Observational, Follow-up Safety Study in Subjects Previously Implanted With VC-01™ Combination Product
An Open-Label, First-In-Human Study Evaluating the Safety, Tolerability, and Efficacy of VC-02™ Combination Product in Subjects With Type 1 Diabetes Mellitus and Hypoglycemia Unawareness
A One-year, Multicenter, Non-Interventional, Follow-up, Safety Study in Subjects Previously Implanted With VC-02™ Combination Product
Learn more about our clinical trials
The Alpha Stem Cell Clinic at UC San Diego Health can provide administrative and other relevant support to scientists and physicians at various stages of development and implementation of clinical trials using stem cell-related therapies.
- Support the development of regulatory strategies
- Assess source material
- Assist product classification
- Facilitate communication with the United States Food and Drug Administration (FDA) (e.g., pre-pre-IND meeting)
- Assist initial documentation and document control
- Facilitate communication and compliance with the FDA (e.g., pre-IND meeting)
- Support the preparation of an Investigational New Drug (IND) application or cross reference
- Prepare and submit regulatory documentation
- Assist trial billing set-up and maintenance support
- Assist with patient care coordination and support
- Schedule clinical trial protocol procedures
- Assist biospecimen collection, shipping, and follow-up of research protocol studies
- Provide trial monitoring
- Data management planning and implementation
Division of Regenerative Medicine
The Division of Regenerative Medicine at UC San Diego School of Medicine is dedicated to delivering superb state-of-the-art clinical care and bringing the advancement of scientific research in regenerative medicine to the forefront of public and scientific spheres both locally and globally.
Blood and Marrow Transplant Program
UC San Diego Health / Sharp HealthCare Joint Blood and Marrow Program is the largest blood and marrow transplant (BMT) program in San Diego, one of the largest in California, and a national leader in physician expertise and state-of-the-art treatment.
Sanford Surgical Training Center
The Sanford Surgical Training Center supports pre-clinical studies and hands-on training of neurosurgical techniques. Experimental models of spinal and peripheral nerve injury are available for testing pre-clinical cell replacement therapies, clinical immunosuppression protocols in allogeneic and syngeneic cell grafting designs, and organ experimentation and cell grafting. Qualified investigators may be trained on the use of FDA-approved spinal and brain injection devices. The Sanford Surgical Training Center is also working to partner with local contract research organizations (CROs) to develop the infrastructure and administrative support needed to conduct good laboratory practice (GLP) studies.
Translational Regenerative Medicine Course
Current Enrollment Period: Spring 2018
The UC San Diego CIRM Alpha Stem Cell Clinic is committed to educating patients and professionals, including study staff. We are pleased to invite all clinical research professionals, from coordinators to physicians, to enroll in
Translating Stem Cells (CLRE-237).
This 20 hour course is offered via
CTRI CREST program. The course may also count as an elective in the
MAS program, but applicants do not necessarily need to be enrolled in either the CREST or MAS program to take this course!
The enrollment period is currently closed. Please contact CTRI CREST program with questions, and
See this downloadable flyer for more information.
Betty Cabrera, MPH, CCRC
Clinical Operations Manager, UC San Diego CIRM Alpha Stem Cell Clinic
Third Annual CIRM Alpha Stem Cell Clinics Network Symposium
UCLA-UC Irvine, April 19, 2018
The UCLA-UC Irvine CIRM Alpha Stem Cell Clinic hosted the 2018 Symposium, "Delivery of Stem Cell Therapeutics to Patients." This symposium highlighted the CIRM Alpha Stem Cell Clinic Network, focusing on what has been achieved to date, and the participants discussed the pathways to commercialization and reimbursement of newly developed therapies.
See the agenda for a list of speakers
Fourth Annual UC San Diego Division of Regenerative Medicine Symposium
UC San Diego, March 9, 2018
Watch these talks all in one place on YouTube
The UC San Diego Division of Regenerative Medicine held its 4th Annual Symposium on Friday, March 9, 2018 at Sanford Consortium for Regenerative Medicine.
This symposium brought together stakeholders from academia, industry, government and the public to discuss developments needed to turn stem cell-based therapies into approved products for patients in need. The program highlighted stem cell regeneration in different disease areas and developments with industry partners. An interactive discussion panel addressed the pitfalls and successes of current stem cell clinical trials.
See the agenda for a list of speakers
Virtual Grand Rounds
For more information about the program, please contact:
Betty Cabrera, MPHPhone: 858-534-5932
Clinical Operations Manager, CIRM Alpha Stem Cell Clinic
Meet our stem cell physicians:
Catriona Jamieson, MD, PhD
Deputy Director, Sanford Stem Cell Clinical Center
Program Director, CIRM Alpha Stem Cell Clinic at UC San Diego Health
Eric Adler, MD
Trial Expert, Cardiology
Edward Ball, MD
Clinical Advisor, UC San Diego CIRM Alpha Stem Cell Clinic
Director, Blood & Marrow Transplant Program
Michael Choi, MD
Trial Expert, Hematology/Blood Diseases
Wolfgang Dillmann, MD
Trial Expert, Endocrinology
Chair & Helen M. Ranney Distinguished Professor of Medicine
John Evans, PhD
Ethics, Policy & Counseling Task Force Lead
Professor of Sociology
Associate Dean, Division of Social Science
Gary Firestein, MD
Professor of Medicine
Dean & Associate Vice Chancellor of Translational Medicine
Director, Clinical and Translational Research Institute (CTRI)
Thomas Kipps, MD, PhD
Trial Expert, Cancer
Evelyn & Edwin Tasch Chair in Cancer Research
Deputy Director of Research Operations, Moores Cancer Center
Martin Marsala, MD
Trial Expert, Neurosurgical technique
Sheldon Morris, MD, MPH
Data Management Lead, CIRM Alpha Stem Cell Clinic at UC San Diego Health
John Ravits, MD
Trial Expert, Neurology
To view the Alpha Clinic's full multidisciplinary team, please see our
Leadership and Staff and
Meet the Experts pages.
"Meet the experts" videos
Meet our stem cell experts in this
For more information about the Alpha Stem Cell Clinic at UC San Diego Health, please call 844-317-STEM (7836) or email