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Management of Elevated INRs

 

INR Symptoms Recommendations
INR > therapeutic < 5No significant bleedingOmit a dose
Resume at a lower dose
RTC in 1 week
INR 5-6No significant bleedingOmit a dose
Consider 500mcg po Vitamin K
(available OTC)
RTC in 1 week
INR 6-9Consider ER referral if high risk for bleedOmit a dose
Consider 2.5mg po Vitamin K
Check INR daily
INR > 9Consider ER referral if high risk for bleedOmit a dose
Consider 5mg po Vitamin K
Check INR daily
Any INRSerious or life-threatening bleedED referral
 

 

  • Increase or decrease oral Vitamin K administration based on the clinical situation.
  • Parenteral Vitamin K should only be used for life-threatening bleeding and is therefore not appropriate for outpatient use.
  • Use the recommendations for the next lower INR range in the following situations:
    1. High initial INR – First 7 days are rapid suppression of Factor VII 
      (the faster the INR goes up, the faster it comes down)
    2. High thrombosis risk – First 30 days following venous thromboembolism
    3. Active malignancy
    4. Antiphospholipid Antibodies (APLA)
    5. Femoral Bypass Graft  
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