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Cancers Treated with HIPEC

Some types of cancers are very difficult to treat. Cancer that has spread to the lining surfaces of the peritoneal (abdominal) cavity from primary colorectal cancer, appendiceal cancer, or mesothelioma and pseudomyxoma peritonei — known as peritoneal carcinomatosis — are such cancers.

Cytoreductive surgery followed by HIPEC is a comprehensive surgical treatment for certain patients with malignancies arising from or confined to the peritoneal cavity, including:

  • Pseudomyxoma peritonei: A buildup of mucus in the peritoneal cavity. The mucus may come from ruptured ovarian cysts, the appendix, or from other abdominal tissues, and mucus-secreting cells may attach to the peritoneal lining and continue to secrete mucus.
  • Mucinous adenocarcinoma of appendix: A type of cancer that begins in cells that line the appendix and produce mucin (the main component of mucus)
  • Peritoneal mesothelioma: A benign (noncancerous) or malignant (cancerous) tumor affecting the lining of the abdominal cavity 
  • Colorectal carcinoma: Cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus)

Members of our team may also collaborate with other Moores Cancer Center surgeons treating other cancer types, including gynecologic oncologists treating advanced ovarian cancer.

See Peritoneal Surface Malignancies and HIPEC for an overview of these cancers and the HIPEC treatment.

Are you a candidate for HIPEC?

Many of the cancers treated with HIPEC are diseases treated by multiple disciplines in medicine and surgery. It is important that a patient discusses HIPEC therapy with their oncologist and surgeon, who can guide their therapy appropriately. A consultation with our physicians near the time of diagnosis will help you to determine if you can benefit from HIPEC and formulate a comprehensive treatment plan. 

Items that we may need for your office visit include:

  • Recent radiology films and reports (CT, PET, MRI) of abdomen, pelvis and chest
  • Pathology report
  • Tumor markers: CEA, CA 19-9, CA 125
  • Operative notes from all prior surgeries related to this disease
  • Summary of all chemotherapy treatment regimens

A clinical consultation with our surgical oncologists is an opportunity to evaluate your medical history and discuss appropriate treatments. They will help determine if HIPEC is right for you. 

Patients with minimal or low-volume disease may be candidates for a clinic trial exploring the possibility of a minimally invasive surgery, which uses smaller incisions and can result in a shorter recovery period. (Watch a video of Dr. Kaitlyn Kelly describing minimally invasive HIPEC.)

Alternatives to HIPEC

If HIPEC is not the recommended treatment for a peritoneal surface malignancy — if the characteristics or location of a tumor make it impossible to remove all visible cancer, for instance — our physicians can recommend other options, including immunotherapy, personalized cancer treatment, or our rare tumors program.

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