HIPEC stands for heated intraperitoneal chemoperfusion, a procedure used to treat
advanced abdominal cancers. You may have heard of HIPEC under another name: IPHC, chemo-bath, HIIC (heated intraoperative intraperitoneal chemotherapy), intraperitoneal chemohyperthermia, or continuous hyperthermic peritoneal perfusion.
HIPEC, a form of chemotherapy during surgery, is performed at the end of surgery to remove abdominal tumors. Once all visible tumors have been removed (called “cytoreduction”), the surgeon continuously circulates a heated, sterile chemotherapy solution throughout the peritoneal cavity for up to 90 minutes. The HIPEC procedure is designed to attempt to kill any remaining cancer cells that cannot be seen. The solution is then removed and the incision closed.
Giving the chemotherapy in the abdomen at the time of surgery allows for greater concentrations of the drug where it is needed. Adding heat has a threefold advantage:
- Heat above 41 degrees Celsius more effectively kills cancer cells while having fewer effects on normal cells.
- Heat allows the chemotherapy to penetrate a few millimeters and kill cancer cells that cannot be seen.
- The chemotherapy dose can be higher than that given intravenously because it is not absorbed by the body in the same way. In this way, the normal side effects of chemotherapy can be avoided.
There is substantial clinical evidence that HIPEC is an effective treatment for patients with pseudomyxoma peritonei, mucinous adenocarcinoma of the appendix, and peritoneal mesothelioma. Additionally, peritoneal metastases from colon cancer can be successfully treated in a significant number of patients. For more information, see
Cancers That Can Be Treated with HIPEC
Leaders in the Field
The UC San Diego Health team is one of the most experienced in the world at this procedure. Our three surgeons are experts in complex abdominal surgery for peritoneal metastates. They have performed hundreds of cytoreductive/HIPEC surgeries, and typically perform 2–3 procedures a week. We have a highly experienced staff as well, including seasoned nurses, medical oncologists, and others familiar with the needs of patients undergoing cytoreductive surgery and HIPEC. For more information, see our physician bios below or
HIPEC Outcome Data.
HIPEC in the News
Our experts have been profiled by CBS Evening News, The New York Times, and numerous other media outlets. Find news stories on HIPEC, along with articles published in medical journals about the procedure.
Clinical trial: Minimally invasive HIPEC
Patients with minimal or early-stage disease may be candidates for a clinical trial exploring the possibility of minimally invasive surgery, which uses smaller incisions and can result in a shorter recovery period. In this video, Dr. Kelly discusses how we are exploring minimally invasive techniques for several complex cancer surgeries, including cytoreduction with HIPEC.