Dosing
Enoxaparin (Lovenox)—comes in prefilled syringes 30mg, 40mg, 60mg, 80mg, 100mg, 120mg, 150mg
- Therapeutic enoxaparin = 1.5mg/kg/day or 1mg/kg/bid
- Prophylactic enoxaparin = 40mg/day
- Dose adjustment required/precaution advised for CrCl < 30mL/min
- Dose adjustment required/precaution advised for obese patients with a BMI ≥ 40 kg/m2. Consider enoxaparin 0.75 mg/kg bid (therapeutic dosing) and enoxaparin 0.5 mg/kg (prophylactic dosing). Consider anti-Xa monitoring.
- Round all enoxaparin doses to the nearest injection syringe availability. Do not have patients displace or “squirt out” some of the medication prior to administration
Dalteparin (Fragmin)—comes in prefilled syringes 2500units, 5000units, 7500units, 10,000units, 12,500units, 15,000units, 18,000units, 25,000units
- Therapeutic dalteparin = 200units/kg/day
- Prophylactic dalteparin = 2500-5000units/day
- Dose adjustment required/precaution advised for CrCl < 30mL/min
- 5000 units/day may be reasonable for patients undergoing dialysis based on a study from 2010