Translate this website into the following languages:

Close Tab
UC San Diego Health
menu iconMenu
search iconSearch

New Role Found for a Cardiac Progenitor Population


May 15, 2008  |  

In a discovery that could one day lead to an understanding of how to regenerate damaged heart tissue, researchers at the University of California, San Diego have found that parent cells involved in embryonic development of the epicardium – the cell layer surrounding the outside of the heart – give rise to three important types of cells with potential for cardiac repair.

In a study published online May 14 in advance of publication in the journal Nature, researchers led by Sylvia Evans, Ph.D., professor of pharmacology at the Skaggs School of Pharmacy and Pharmaceutical Sciences and professor of medicine at UC San Diego, discovered in mice that developing embryonic cells that form the epicardium develop into cardiomyocytes, or muscle cells, as well as into connective tissue and vascular support cells of the heart. 

The UCSD team generated mice which enabled lineage studies of epicardial cells, utilizing a marker for these lineages called a T-box transcription factor, Tbx18.  “The surprising finding was that during the earliest stages of development, myocytes are also generated from parent cells within the embryonic epicardium,” said Evans.  The Evans lab went on to demonstrate that, in the adult mouse, epicardial cells have lost their earlier embryonic ability to generate cardiomyocytes.

“Our findings raise the possibility that if we can restore the ability of adult epicardial cells in mammals to generate cardiomyocytes, it may enhance their future potential for cardiac repair following injury, such as a heart attack,” said co-first author Jody C. Martin of UCSD’s Department of Bioengineering.

While the adult mammalian heart has lost this capacity to generate new heart muscle, according to Evans, other investigators have demonstrated that zebrafish can fully regenerate their hearts following injury.  This regeneration is associated with migration of Tbx 18-expressing cells to the site of injury, and the new formation of cardiomycytes.  If Tbx18-cell migration is prevented, there is no repair. The UCSD researchers’ findings suggest that one reason that zebrafish can regenerate their hearts may be that adult zebrafish epicardium somehow retains the capacity to generate cardiomyocytes.

Additional contributors to the paper include co-first authors Chen-Leng Cai andYunfu Sun, as well as Li Cui, Lei Bu, Lei Yang and Xiaoxue Zhang, UCSD’s Skaggs School of Pharmacy; Ju Chen, Kunfu Ouyang and Xingqun Liang, UCSD Department of Medicine; Andrew McCulloch, UCSD Department of Bioengineering; Lianchun Wang, University of Georgia; William B. Stallcup, The Burnham Institute, La Jolla, California; and Christopher P. Denton, Royal Free and University College Medical School, London.  The research was funded in part by a grant from the National Institutes of Health and an American Heart Association Scientist Development grant.

# # #

Media Contact: Debra Kain,, 619-543-6163


Media Contact

Share This Article

Related News

While astronauts on long space missions do not experience a change in spinal disc height, the muscles supporting the spine weaken, find researchers at University of California San Diego School of Medi ...
There are many unanswered questions about the mechanisms that contribute to the onset of type 1 diabetes. Researchers at University of California San Diego School of Medicine hope to answer some of th ...
Viruses hijack the molecular machinery in human cells to survive and replicate, often damaging those host cells in the process. Researchers at the University of California San Diego School of Medicine ...
Although only 10 percent of amyotrophic lateral sclerosis (ALS) cases are hereditary, a significant number of them are caused by mutations that affect proteins that bind RNA, a type of genetic materia ...

Follow Us

Our bimonthly newsletter delivers healthy lifestyle tips, patient stories and research discovery news. Subscribe: