CIRM Awards $5 Million Early Translational Grant to UC San Diego Researcher

 

April 30, 2009  |  

A stem cell researcher from the University of California, San Diego, Yang Xu, professor of biology, has been awarded a $5.16 million grant from the California Institute for Regenerative Medicine (CIRM).  Fifteen Early Translational grants, totaling $67.7 million, were approved at the April 29 meeting of the Independent Citizens’ Oversight Committee to fund work that translates basic research into clinical cures.

“This Early Translational grant will enable Dr. Xu and researchers at UC San Diego to develop improved models of human disease,” said Larry Goldstein, PhD, director of UC San Diego’s Stem Cell Program. “Our hope is that these models will provide scientists and biotech companies with more reliable ways to test drugs for safety and efficacy.”

Xu’s research uses induced pluripotent stem cells (iPSCs), which are very similar to human embryonic stem cells (hESCs). Generated from a patient’s somatic cells, pre-existing cells that no longer differentiate, iPSCs could provide an ideal cell source for transplantation by avoiding graft rejection in the patient.  Xu and colleagues propose to eliminate the cancer risk associated with pluripotent stem cells and develop mouse models with a functional human immune system in order to study immune responses and tolerance during cell transplantation. 

“This new translational grant will allow us to establish extensive collaboration with other physician scientists to solve the issues of cancer risk and immune rejection associated with pluripotent stem cell-based therapy,” said Xu.

The latest round of CIRM funding brings the total grants to the UC San Diego Stem Cell Program to close to $45 million since grants were first awarded in late 2005. 

###

Media Contact: Debra Kain, 619-543-6163, ddkain@ucsd.edu




Media Contact

Share This Article


Related News

5/21/2019
Neonatal exposure to nicotine alters the reward circuity in the brains of newborn mice, increasing their preference for the drug in later adulthood, report researchers at University of California San ...
5/21/2019
University of California San Diego School of Medicine research expands and deepens the association between clinical depression and pain, identifying specific regions of the brain that drive, influence ...
5/20/2019
UC San Diego researchers discover new role for epidermal growth factor receptor in blood stem cell development, a crucial key to being able to generate them in the laboratory, and circumvent the need ...
5/16/2019
In its first-ever assessment of biomedical institutions around the world, based upon published research in a targeted set of high-quality scientific journals, the 2019 Nature Index ranked University o ...



Follow Us