UCSD Receives $10 Million NIH Grant to Lead Hypoxia Tolerance Research Study

 

September 23, 2010  |  

Gabriel G. Haddad, MD, chair of the Department of Pediatrics at the University of California, San Diego School of Medicine and Physician-in-Chief at Rady Children’s Hospital-San Diego has received a $10 million grant from the National Institute of Health’s Heart, Lung and Blood Institute.

Gabriel Haddad

Gabriel G. Haddad, MD

A world renowned physician-scientist in pediatric pulmonary medicine, Haddad will lead a collaborative team of investigators from UC San Diego and the Sanford-Burnham Medical Research Institute to study the impact of low oxygen levels on cells and tissue in the heart, lung, and brain.

“Understanding the molecular, cellular, and genetic mechanisms that contribute to low oxygen tolerance or susceptibility will have a major impact on our treatments of central nervous system and cardio-respiratory diseases such as stroke, myocardial ischemia/infarction, obstructive sleep apnea and pulmonary hypertension,” said Haddad.

The overall aims of this project are:

  • To study the adaptive mechanisms to hypoxia in cardiovascular and respiratory systems at both cellular and molecular levels
  • To study the fundamental genetic mechanisms of tolerance in a Drosophila (fruit fly) model
  • To modulate or manipulate molecular mechanisms in mammalian cells/tissues/animals to render them hypoxia-tolerant after learning from a tolerant organism, e.g., the fly
  • To identify molecular signatures of hypoxia tolerance and susceptibility that may be predictive clinically

The investigative team includes Jason Yuan, MD, PhD, professor, Pulmonary, Critical Care, and Sleep Medicine, University of Illinois at Chicago; Rolf Bodmer, PhD, professor and director, Development and Aging Program, Sanford-Burnham Institute for Medical Research; Andrew McCulloch, PhD, professor, UCSD Department of Bioengineering; Giovanni Paternostro, MD, PhD, assistant professor, The Sanford-Burnham Institute for Medical Research; and Frank Powell, PhD, professor, UCSD Department of Medicine and director, University of California’s White Mountain Research Station.

# # #

Media Contact: Debra Kain, 619-543-6163, ddkain@ucsd.edu




Media Contact

Share This Article


Related News

5/22/2017
On Sunday, May 21, the Student Run Free Clinic Project at UC San Diego was recognized by the American Psychiatric Association (APA) for excellence in caring for the community. For two decades, the Stu ...
5/22/2017
Liver cirrhosis is the 12th leading cause of mortality worldwide and approximately half of those deaths are due to alcohol abuse. Yet apart from alcohol abstinence, there are no specific treatments to ...
5/21/2017
Among 12- to 17-year-olds who have never used tobacco products, nearly half were considered receptive to tobacco marketing if they were able to recall or liked at least one advertisement, report resea ...
5/11/2017
Researchers at University of California San Diego School of Medicine, with collaborators across the nation, have determined that magnetic resonance elastography (MRE) can be an accurate, non-invasive ...



Follow Us