UC San Diego Researcher Awarded $3.8 Million for New Path to Breast Cancer Therapy

 

September 29, 2010  |  

Seth Field, MD, PhD, associate professor in the Department of Medicine at UC San Diego, has been awarded a five-year, $3.86 million “Era of Hope Scholar Award” from the Department of Defense Breast Cancer Research Program.  The award supports individuals who have high potential for innovation in breast cancer research early in their careers, researchers considered the “best and brightest” in their field through “extraordinary creativity, vision and productivity and potential for leadership in the breast cancer research community.

Seth Field

Seth Field, MD, PhD

Field was one of two scientists selected in the global competition.  His project “A New Path to Breast Cancer Therapy” will investigate the mechanism by which a lipid-binding protein called GOLPH3 contributes to cancer.

Recently, Field and colleagues discovered part of the mechanism involving GOLPH3 by which cells export proteins. Interestingly, the gene that encodes GOLPH3 is also a cancer gene that is commonly amplified in human cancers, including approximately one third of breast cancers. Although unprecedented, the identification of GOLPH3 as a cancer gene – together with his discovery of its role in a three-way interaction that is required for efficient extracellular transport – implicates the process of protein export in the development of cancer.

This award will fund experiments to determine the mechanism by which GOLPH3 causes cancer, the role of protein export in this process, and the suitability of the GOLPH3 pathway as a candidate target for new types of breast cancer therapy.

In 2008, Field was a winner of the NIH New Innovator award to study the function of the group of lipid signaling molecules called phosphoinositides and their target proteins such as GOLPH3.  These are molecules which are known to play critical roles in regulating cell growth and death, metabolism, and communication processes within cells. 

# # #

Media Contact: Debra Kain, 619-543-6163, ddkain@ucsd.edu

 


Related Specialties

Cancer



Media Contact

Share This Article


Related News

10/19/2017
University of California San Diego researchers have developed the first 3D spatial visualization tool for mapping “’omics” data onto whole organs. The tool helps researchers and clinicians understand ...
10/18/2017
Modeling the interplay between neurons and astrocytes derived from children with Autism Spectrum Disorder (ASD), researchers at University of California San Diego School of Medicine, with colleagues i ...
10/10/2017
Despite a diagnosis of stage IV pancreatic cancer and ongoing chemotherapy, Mike Levine boarded a plane this past weekend destined for Kona, Hawaii, where he will compete in one of the most grueling o ...
10/10/2017
Approximately 10 percent of Americans take a proton pump inhibitor drug to relieve symptoms of frequent heartburn and acid reflux. That percentage can be much higher for people with chronic liver dise ...



Follow Us