UCSD Receives $10 Million NIH Grant to Lead Hypoxia Tolerance Research Study

 

September 23, 2010  |  

Gabriel G. Haddad, MD, chair of the Department of Pediatrics at the University of California, San Diego School of Medicine and Physician-in-Chief at Rady Children’s Hospital-San Diego has received a $10 million grant from the National Institute of Health’s Heart, Lung and Blood Institute.

Gabriel Haddad

Gabriel G. Haddad, MD

A world renowned physician-scientist in pediatric pulmonary medicine, Haddad will lead a collaborative team of investigators from UC San Diego and the Sanford-Burnham Medical Research Institute to study the impact of low oxygen levels on cells and tissue in the heart, lung, and brain.

“Understanding the molecular, cellular, and genetic mechanisms that contribute to low oxygen tolerance or susceptibility will have a major impact on our treatments of central nervous system and cardio-respiratory diseases such as stroke, myocardial ischemia/infarction, obstructive sleep apnea and pulmonary hypertension,” said Haddad.

The overall aims of this project are:

  • To study the adaptive mechanisms to hypoxia in cardiovascular and respiratory systems at both cellular and molecular levels
  • To study the fundamental genetic mechanisms of tolerance in a Drosophila (fruit fly) model
  • To modulate or manipulate molecular mechanisms in mammalian cells/tissues/animals to render them hypoxia-tolerant after learning from a tolerant organism, e.g., the fly
  • To identify molecular signatures of hypoxia tolerance and susceptibility that may be predictive clinically

The investigative team includes Jason Yuan, MD, PhD, professor, Pulmonary, Critical Care, and Sleep Medicine, University of Illinois at Chicago; Rolf Bodmer, PhD, professor and director, Development and Aging Program, Sanford-Burnham Institute for Medical Research; Andrew McCulloch, PhD, professor, UCSD Department of Bioengineering; Giovanni Paternostro, MD, PhD, assistant professor, The Sanford-Burnham Institute for Medical Research; and Frank Powell, PhD, professor, UCSD Department of Medicine and director, University of California’s White Mountain Research Station.

# # #

Media Contact: Debra Kain, 619-543-6163, ddkain@ucsd.edu




Media Contact

Share This Article


Related News

6/15/2018
Researchers at University of California San Diego School of Medicine suggest higher levels of vitamin D are associated with decreasing risk of breast cancer. Their epidemiological study is published i ...
6/13/2018
Neglected tropical diseases are a group of chronic and disabling parasitic infections that primarily affect poor and underserved communities. These diseases affect more than 1 billion people globally, ...
6/12/2018
The unique composition of a mother’s breastmilk may help to reduce food sensitization in her infant, report researchers at the University of California San Diego School of Medicine with colleagues in ...
6/6/2018
Patients at UC San Diego Health can now read the medical notes signed by their primary care physician. This move toward transparency is part of an international trend to make patients feel more in con ...



Follow Us