Coronavirus (COVID-19) updates for UC San Diego Health patients and visitors. Learn More

Menu
Search

UC San Diego Researcher Awarded $3.8 Million for New Path to Breast Cancer Therapy

 

September 29, 2010  |  

Seth Field, MD, PhD, associate professor in the Department of Medicine at UC San Diego, has been awarded a five-year, $3.86 million “Era of Hope Scholar Award” from the Department of Defense Breast Cancer Research Program.  The award supports individuals who have high potential for innovation in breast cancer research early in their careers, researchers considered the “best and brightest” in their field through “extraordinary creativity, vision and productivity and potential for leadership in the breast cancer research community.

Seth Field

Seth Field, MD, PhD

Field was one of two scientists selected in the global competition.  His project “A New Path to Breast Cancer Therapy” will investigate the mechanism by which a lipid-binding protein called GOLPH3 contributes to cancer.

Recently, Field and colleagues discovered part of the mechanism involving GOLPH3 by which cells export proteins. Interestingly, the gene that encodes GOLPH3 is also a cancer gene that is commonly amplified in human cancers, including approximately one third of breast cancers. Although unprecedented, the identification of GOLPH3 as a cancer gene – together with his discovery of its role in a three-way interaction that is required for efficient extracellular transport – implicates the process of protein export in the development of cancer.

This award will fund experiments to determine the mechanism by which GOLPH3 causes cancer, the role of protein export in this process, and the suitability of the GOLPH3 pathway as a candidate target for new types of breast cancer therapy.

In 2008, Field was a winner of the NIH New Innovator award to study the function of the group of lipid signaling molecules called phosphoinositides and their target proteins such as GOLPH3.  These are molecules which are known to play critical roles in regulating cell growth and death, metabolism, and communication processes within cells. 

# # #

Media Contact: Debra Kain, 619-543-6163, ddkain@ucsd.edu

 


Related Specialties

Cancer



Media Contact

Share This Article


Related News

9/21/2020
Moores Cancer Center at UC San Diego Health is using advanced imaging, genomics, personalized medicine and new therapies to treat patients like Brian McCloskey, who has stage IV prostate cancer.
9/17/2020
A consortium of 12 health systems, led by UC San Diego Health, introduces COVID19questions.org, a site where clinicians, researchers, patients and the general public are invited to submit questions th ...
9/16/2020
Early detection and intervention stanched the first known introductions of the SARS-CoV-2 virus into North America and Europe, validating the effectiveness of quick, comprehensive testing and contact ...
9/15/2020
UC San Diego Health is the first hospital on the West Coast to perform heart transplant surgery from a donor after circulatory death using a new portable organ care system. The investigational procedu ...



Follow Us