Multiple Brain Regions Moderate and Link Depressive Mood and Pain

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​Depression is linked to diminished activity in parts of the brain believed to regulate mood, which previous research suggests may explain why depressed persons display an lessened ability to govern their ruminative thought process.

In a new paper published online in advance of print, researchers at University of California San Diego School of Medicine expand and deepen that understanding, identifying specific regions of the brain that drive, influence and moderate depressive mood and its relationship to perceiving physical pain.

Writing in the journal PAIN, a team headed by senior author Fadel Zeidan, PhD, assistant professor of anesthesiology at UC San Diego School of Medicine, with colleagues in North Carolina and Ohio, found both executive function regions of the brain and areas monitoring sensory input were involved in both pain and negative mood, both high and low levels.

“We were very surprised about the expansive roles of these regions,” said Zeidan. “Brain regions involved in facilitating pain were also associated with lower pain and depression. Brain regions involved in regulating pain where also associated with increasing depression. Perhaps it’s not surprising after seeing the results. Why shouldn’t specific aspects of the brain perform multiple roles?”

In their study, Zeidan and colleagues studied 76 healthy, non-depressed and pain-free individuals who were first given a standardized assessment of negative mood and depression, then exposed to an unpleasant thermal (heat) stimulus while undergoing magnetic resonance scanning.

The data revealed that the prefrontal cortex — a region of the brain that manages higher level executive functions like cognition, memory and behavior — also moderated pain perception, along with sensory discrimination areas, such as the secondary somatosensory cortex and posterior insula.

They found that participants with higher levels of depressive mood exhibited heightened sensitivity of experimental pain, with greater activation in all of the involved brain regions.

“These findings illuminate the complex relationship between depressive mood and pain,” said Zeidan. “We also hope that we can use these findings to better refine the development of novel behavioral and non-opioid-based therapies that target the comorbid nature of chronic pain and clinical depression, leading to better treatments for both.”

Co-authors include: Adrienne L. Adler-Neal, Nichole M. Emerson, Suzan R. Farris and Youngkyoo Jung, Wake Forest School of Medicine; and Robert C. Coghill, Cincinnati Children’s Hospital Medical Center.

Funding for this research came, in part, from the National Center for Complementary and Integrative Health (R21-AT007247, F32-AT006949, K99-AT008238, R00-AT008238, F30-AT009165, R01-AT009693), The National Institute of Neurological Disorders and Stroke (R01-NS239426), the Mind and Life Institute Francisco J. Varela Award and the Wake Forest Center for Integrative Medicine.


Behavioral & Mental Health Care Neurological Care Pain Management

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