Metabolic syndrome is the name for a group of risk factors, such as high blood pressure and cholesterol levels, that increase the risk for adverse health issues, from heart disease and diabetes to stroke. Eating healthier, getting more exercise and taking prescribed medications when needed are common remedies but often prove insufficient to fully managing risks.
In a recent collaborative effort, researchers from University of California San Diego School of Medicine and the Salk Institute for Biological Studies reported a form of intermittent fasting, called time-restricted eating, improved the health of study participants who had been diagnosed with metabolic syndrome.
The pilot study, published online in the December 5, 2019 edition of Cell Metabolism, found that when participants restricted their eating to 10 hours or less over a period of 12 weeks, they lost weight, reduced abdominal fat, lowered blood pressure and cholesterol and enjoyed more stable blood sugar and insulin levels.
“As a cardiologist, I find it is very hard to get patients with prediabetes or metabolic syndrome to make lasting and meaningful lifestyle changes,” said Pam Taub, MD, co-corresponding author and associate professor of medicine at UC San Diego School of Medicine and cardiologist at the Cardiovascular Institute at UC San Diego Health. “There is a critical window for intervention with metabolic syndrome. Once people become diabetic or are on multiple medications, such as insulin, it’s very hard to reverse the disease process.
“Metabolism is closely linked with circadian rhythms, and knowing this, we were able to develop an intervention to help patients with metabolic syndrome without decreasing calories or increasing physical exercise.”
Time-restricted eating (eating all calories within a consistent 10-hour window) allows individuals to eat in a manner that supports their circadian rhythms and their health. Circadian rhythms are the 24-hour cycles of biological processes that affect nearly every cell in the body. Erratic eating patterns can disrupt this system and induce symptoms of metabolic syndrome, including increased abdominal fat and abnormal cholesterol or triglycerides.
“Time-restricted eating is a simple dietary intervention to incorporate, and we found that participants were able to keep the eating schedule,” said Satchin Panda, PhD, co-corresponding author and professor in Salk’s Regulatory Biology Laboratory. “Eating and drinking everything (except water) during a 10-hour window allows your body to rest and restore for 14 hours at night. Your body can also anticipate when you will eat, so it can prepare the body to optimize metabolism.”
The study involved 19 participants diagnosed with metabolic syndrome, with 16 taking at least one medication, like a statin. Participants used an app created by Panda called myCircadianClock to log when and what they ate during an initial two-week baseline period followed by three months of 10-hour time-restricted eating per day. They were told they could decide what time to eat and how much to eat as long as all food consumption occurred within a 10-hour window.
At the end of the 12 weeks, participants averaged a 3 percent reduction in weight and body mass index (BMI) and a 4 percent reduction in abdominal/visceral fat. Many also experienced reductions in cholesterol and blood pressure and improvements in fasting glucose. Seventy percent of participants reported an increase in sleep satisfaction or in the amount they slept. “Patients also reported that they generally had more energy, and some were able to have their medications lowered or stopped after completing the study,” said Taub.
More than two-thirds of participants continued with time-restricted eating for up to a year after the study concluded — at least part of the time. “Adapting this 10-hour time-restricted eating is also a cost-effective method for reducing symptoms of metabolic syndrome and improving health,” said Panda. “By delaying the onset of diabetes by even one year in a million people with prediabetes, the intervention could save roughly $9.6 billion dollars in health care costs.”
The researchers are currently conducting another clinical trial to examine the benefits of time-restricted eating in a larger group of more than 100 participants with metabolic syndrome. The study examines additional measures that will help the researchers investigate changes in body composition and muscle function.
“Knowing how to optimize circadian rhythms could lead to a new treatment option for metabolic syndrome patients with life-altering diseases,” said Taub.
Co-authors include: Michael Wilkinson, Adena Zadourian and Hannah Lo, UC San Diego; and Emily Manoogian, Savannah Fakhouri, Azarin Shoghi, Xinran Wang, Jason Fleischer, and Saket Navlakha, Salk Institute.
Funding for this research came, in part, from the National Institutes of Health (DK118278 and DK115214), the Department of Homeland Security (EMW-2016-FP-00788), the Department of Defense (W81XWH1810645), The Leona M. and Harry B. Helmsley Charitable Trust grant (2012-PG-MED002), the Robert Wood Johnson Foundation, the University of California San Diego Public Health Pilot Grant, the American College of Cardiology (ACC)/Merck Research Fellowship Award, the Larry L. Hillblom Foundation Postdoctoral Fellowship and Salk Women in Science Fellowship.
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