Potential New Drug Class Hits Multiple Cancer Cell Targets, Boosting Efficacy and Safety

 

February 01, 2017  |  

MYC is a regulator gene. It controls the expression of other genes and codes transcription factors or proteins involved in many fundamental cellular processes. It’s also among the most frequently altered genes found in cancer, making it a profoundly attractive target for cancer therapies.

But MYC has proved very complicated and an elusive therapeutic target. In a new paper published this week in PNAS, researchers at the University of California San Diego School of Medicine and Moores Cancer Center, in collaboration with colleagues at Rady Children’s Hospital-San Diego, the University of Colorado School of Medicine and SignalRx, a San Diego-based biopharmaceutical company, describe a potential new class of anti-cancer drugs that inhibit two or more molecular targets at once, maximizing therapeutic efficiency and safety.

“Most anti-cancer drugs have a single target. They try to do one thing, such as block a single receptor or signaling pathway,” said study co-senior author Donald L. Durden, MD, PhD, professor in the Department of Pediatrics at UC San Diego School of Medicine and associate director for pediatric oncology at Moores Cancer Center at UC San Diego Health. “This paper is proof-of-concept of a completely different mode of drug discovery clearly separated from the standard practice of one drug, one target.”

Specifically, Durden and colleagues engineered a small molecule called SF2523 in silico, using molecular modeling crystal structure and nuclear magnetic resonance imaging, to simultaneously disrupt two key MYC-mediating factors that promote cancer cell growth. Those two factors are PI3K, an enzyme, and BRD4, a protein.

In cell and mouse models, they found SF2523 concomitantly inhibited PI3K and BRD4, blocking MYC activation and expression and markedly inhibiting cancer growth and metastasis, with improved efficacy and less toxicity to the host.

“This is a ‘first in class’ approach to achieve a maximum inhibition of MYC in the treatment of the multitude of cancers known to be driven by the MYC oncogene,” said Durden. “These findings suggest that dual-activity inhibitors are a highly promising lead compound for developing new anticancer therapeutics.”

Co-authors include: Forest H. Andrews, and co-senior author Tatiana G. Kutateladze, University of Colorado School of Medicine; Alok R. Singh, and Shweta Joshi, UC San Diego; and Guillermo A. Morales, and Joseph R. Garlich, SignalRx.

Funding for this research came, in part, from the National Institutes of Health (R01 FD04385, CA192656, R01 GM101664, GM106416, GM100907).

Disclosure: Donald Durden, MD, PhD, is co-founder and a member of the board of directors and scientific advisory board of SignalRx. He also has an equity interest in the company.


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