Coronavirus (COVID-19) updates for UC San Diego Health patients and visitors. Learn More

Menu
Search

UC San Diego Moores Cancer Center Offers New Hope for Deadly Brain Tumor

 

February 03, 2012  |  

One of few clinical trial sites, worldwide

Jim Black is fighting the meanest, most aggressive, most common kind of brain tumor in the United States: recurrent glioblastoma multiforme (GBM).  In the United States, each year, approximately 10,000 patients are affected by GBM.  Now, a novel investigational device – available only at clinical trial sites – is offering new hope to these patients.

The non-invasive procedure – called Tumor Treating Fields (TTF) – is delivered using a portable device – called the NovoTTF-100A System made by Novocure.  The TTF procedure uses alternating electrical fields to disrupt the rapid cell division exhibited by cancer cells. 
 

 Santosh Kesari
Santosh Kesari, MD, PhD, director of Neuro-Oncology at UC San Diego Moores Cancer Center.
“Patients with recurrent GBM present a significant treatment challenge,” said Santosh Kesari, MD, PhD, director of Neuro-Oncology at UC San Diego Moores Cancer Center.  “The initial clinical research for the approval trial demonstrated that, compared to patients who were treated with chemotherapy, patients treated with NovoTTF achieved comparable survival times, had fewer side effects, and reported improved quality of life.”

 

On average, a patient with GBM survives less than 15 months with optimal treatment and only three to five months without additional effective treatment.  The TTF procedure may provide physicians with a fourth treatment option in addition to surgery, radiation therapy and chemotherapy.

TTFs inhibit tumor growth by causing cancerous cells to die.  The TTF procedure is delivered using non-invasive, insulated transducer arrays (electrodes) that are placed directly on the skin in the region of the tumor.  The hat-like collection of electrodes connects to a portable device which is slightly thicker than a laptop and weighs about six pounds.  The device sends a low intensity, alternating electric field into the tumor which prevents the cells from dividing and spreading and causes cancer cells to die. 

The most commonly reported side effect from NovoTTF is a mild-to-moderate scalp rash, beneath the electrodes.  The FDA-approved device is intended as an alternative to standard medical therapy for GBM after surgical and radiation options have been exhausted.

“When all other options have been exhausted, patients are willing to do just about anything to keep the tumor at bay,” said Kesari.  “This device gives them an opportunity to fight back, to feel like they are taking an active, hands-on role in their own treatment, and provides tremendous hope.”

# # #

Media Contact: Kim Edwards, 619-543-6163, kedwards@ucsd.edu


Related Specialties



Media Contact

Share This Article


Related News

4/2/2020
Donations of personal protective equipment, food and money have flooded into UC San Diego Health, part of a community effort to treat and protect patients, staff and the community from COVID-19.
3/26/2020
Researchers at University of California San Diego School of Medicine are launching a pair of studies to answer critical questions regarding the roles COVID-19 may play in breast milk and pregnancy.
3/24/2020
Researchers at four University of California Health medical centers have begun recruiting participants for a Phase II clinical trial to investigate the safety and efficacy of treating adult patients w ...
3/20/2020
Partnering with five diagnostics manufacturers, UC San Diego is significantly ramping up testing for COVID-19, projecting capacity to complete up to 1,500 tests daily within two to three weeks.



Follow Us