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Adult Down Syndrome Program

Dr. Michael Rafii discusses progress in diagnosing and treating Alzheimer's disease in people with Down syndrome, with Dr. William Mobley, chair of neurosciences at UC San Diego.

Down syndrome is the most common genetic cause of learning disabilities in children. It occurs when an individual has three, rather than two, copies of chromosome 21. This additional genetic material alters the course of development and puts children with Down syndrome at risk for a number of health problems during childhood and later in life. People with Down syndrome typically also have mild to moderate cognitive impairment.

Family support and enrichment therapies make a big difference in the lives of both children and adults with Down syndrome. We partner with national and local advocacy organizations and community agencies to provide medical care for adults with Down syndrome who are experiencing cognitive changes due to health issues or aging. We also conduct research studies and clinical trials, and provide assessments and resources for people with Down syndrome.

Our clinic is part of the UC San Diego  Down Syndrome Center for Research and Treatment, one of the first programs in the country to connect academic research with the treatment of Down syndrome for adults with cognitive issues. The ultimate goal of our research is to cultivate treatments that enhance the lives of people with Down syndrome, making it possible for them to achieve more independence.    


Down Syndrome Association of San Diego
Provides family support, education and advocacy to a thousand families and professionals in San Diego County. Affiliated with the National Down Syndrome Society, the National Down Syndrome Congress and the Exceptional Family Resource Center.

DS Action
DS Action raises awareness about Down syndrome and sponsors the pediatric Down Syndrome Center at Rady Children’s Hospital.

National Down Syndrome Society
The national advocate for people with Down syndrome with 350 affiliate groups. NDSS is one of the largest non-government supporters of Down syndrome research in the United States.

Visit the Down Syndrome Center for Treatment and Research for more resources.

Appointments & Referrals

Call 858-657-8540



Clinical Trial Investigates Vaccine for Alzheimer's in Down Syndrome

The Wall Street Journal features Dr. Michael Rafii on the link between Alzheimer's and Down syndrome

Support Advances in Down Syndrome Research

Make a financial gift to UC San Diego Neurological Institute.

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