Treatment-Resistant Depression

If you are struggling with treatment-resistant depression (TRD), you are not alone.

About one-third of Americans who experience depression will not find relief from antidepressant medications and talk therapy. If you are one of these people, we can help.

UC San Diego Health offers interventional psychiatry approaches for adults ages 18 and older with treatment-resistant depression. 

What Is Treatment-Resistant Depression?

Treatment-resistant depression is depression that is hard to treat with antidepressants and talk therapy alone. You likely have treatment-resistant depression if your medications are well managed but you have not responded sufficiently to at least two different antidepressants.

Treatment Options

We use the best available medical science and an understanding of how the brain works to craft a care plan that is both targeted and personalized to your particular response. The following treatment options are available for adults with treatment-resistant depression.

Expert Mental Health Care for Treatment-Resistant Depression

Our clinic is led by Zafiris "Jeff" Daskalakis, MD, PhD, an international expert in brain stimulation who oversees patient treatment protocols. Under his guidance, you receive the most effective and advanced approaches for your depression. You won't find a higher level of expertise in brain stimulation therapies anywhere in the United States.

Behavioral Health Plans Accepted

We accept behavioral health insurance and most insurance plans that are offered to UC San Diego Health employees. You're encouraged to verify that UC San Diego Health is an in-network provider.

Verify Coverage

Depression Symptoms, Causes & Diagnosis

Emergency Help Available 24/7

For a mental health emergency, call 911 or go to the nearest emergency room. You can also call the San Diego Crisis Line at 888-724-7240 for confidential, free support.

UC San Diego Health Emergency Departments