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Cancer of Unknown Primary (CUP)

COVID-19 update: We know that our patients and their families have questions related to care during this time. Please see COVID-19 Information and FAQs for Patients With Cancer for the latest updates.

Cancer of Unknown Primary, also known as CUP or Carcinoma of Unknown Primary, is a rare disease in which cancer cells are found in the body but it is unclear as to where they originated. 

At UC San Diego Health, we offer diagnosis and treatment for CUP cases in our Rare Tumor Clinic, which is part of the Center for Personalized Cancer Therapy at Moores Cancer Center.

Directed by Shumei Kato, MD, our program emphasizes a precision-medicine approach, with clinical trials matching patients to a targeted treatment or immune therapy based on their genomic profile.

Our strategy integrates multiple types of in-depth diagnostic testing in order to better understand the origins of the cancer and its biology. This approach includes expert pathology review and comprehensive genomic and immune profiling and review by Moores Cancer Center’s Molecular Tumor Board.